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Detection of a low-...
Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes
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- Krogvold, Lars (författare)
- Paediatric Department, Oslo University Hospital, Oslo, Norway,Paediatric Dept., Oslo University Hospital, Norway
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- Edwin, Bjørn (författare)
- Intervention Centre and Department of Surgery, Oslo University Hospital, Oslo, Norway Faculty of Medicine, University of Oslo, Oslo, Norway,Intervention Centre and Dept. of Surgery, Oslo University Hospital, and Faculty of Medicine, University of Oslo, Norway
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- Buanes, Trond (författare)
- Faculty of Medicine, University of Oslo, Oslo, Norway Department of Surgery, Oslo University Hospital, Oslo, Norway,Dept. of Surgery, Oslo University Hospital, and Faculty of Medicine, University of Oslo, Norway
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- Frisk, Gun (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Sweden
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- Skog, Oskar (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Sweden
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- Anagandula, Mahesh (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Sweden
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- Korsgren, Olle (författare)
- Uppsala universitet,Klinisk immunologi,Department of Immunology, Genetics and Pathology, Uppsala University, Sweden
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- Undlien, Dag (författare)
- Faculty of Medicine, University of Oslo, Oslo, Norway,Department of Medical Genetics, Oslo University Hospital, Oslo, Norway,Department of Medical Genetics, Oslo University Hospital, and Faculty of Medicine, University of Oslo, Norway
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- Eike, MortenC (författare)
- Department of Medical Genetics, Oslo University Hospital, Oslo, Norway
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- Richardson, Sarah J (författare)
- Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, U.K.,Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, UK
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- Leete, Pia (författare)
- Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, U.K.,Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, UK
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- Morgan, Noel G (författare)
- Institute of Biomedical & Clinical Science, University of Exeter Medical School, Exeter, U.K.,Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, UK
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- Oikarinen, Sami (författare)
- Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
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- Oikarinen, Maarit (författare)
- Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
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- Laiho, Jutta E (författare)
- Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
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- Hyöty, Heikki (författare)
- Department of Virology, School of Medicine, University of Tampere, Tampere, Finland,9Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
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- Ludvigsson, Johnny (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Hanssen, Kristian F (författare)
- Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Endocrinology, Oslo University Hospital, Oslo, Norway,Dept. of Endocrinology, Oslo University Hospital, and Faculty of Medicine, University of Oslo, Norway
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- Dahl-Jørgensen, Knut (författare)
- Paediatric Department, Oslo University Hospital, Oslo, NorwayFaculty of Medicine, University of Oslo, Oslo, Norway,Paediatric Dept. Oslo University Hospital, and Faculty of Medicine, University of Oslo, Norway
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Paediatric Department, Oslo University Hospital, Oslo, Norway Paediatric Dept, Oslo University Hospital, Norway (creator_code:org_t)
- 2014-11-24
- 2015
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 64:5, s. 1682-1687
- Relaterad länk:
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https://diabetes.dia...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The Diabetes Virus Detection study (DiViD) is the first to examine fresh pancreatic tissue at the diagnosis of type 1 diabetes for the presence of viruses. Minimal pancreatic tail resection was performed 3-9 weeks after onset of type 1 diabetes in 6 adult patients (age 24-35 years). The presence of enteroviral capsid protein 1 (VP1) and the expression of class I HLA were investigated by immunohistochemistry. Enterovirus RNA was analyzed from isolated pancreatic islets and from fresh frozen whole pancreatic tissue using PCR and sequencing. Non-diabetic organ donors served as controls. VP1 was detected in the islets of all type 1 diabetes patients (2 of 9 controls). Hyperexpression of class I HLA molecules was found in the islets of all patients (1 of 9 controls). Enterovirus specific RNA sequences were detected in 4 of 6 cases (0 of 6 controls). The results were confirmed in different laboratories. Only 1.7 % of the islets contained VP1 positive cells and the amount of enterovirus RNA was low. The results provides evidence for the presence of enterovirus in pancreatic islets of type 1 diabetic patients, being consistent with the possibility that a low grade enteroviral infection in the pancreatic islets contribute to disease progression in humans.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Diabetes
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Krogvold, Lars
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Edwin, Bjørn
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Buanes, Trond
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Frisk, Gun
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Skog, Oskar
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Anagandula, Mahe ...
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Korsgren, Olle
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Undlien, Dag
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Eike, MortenC
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Richardson, Sara ...
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Leete, Pia
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Morgan, Noel G
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Oikarinen, Sami
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Oikarinen, Maari ...
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Laiho, Jutta E
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Hyöty, Heikki
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Ludvigsson, John ...
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Hanssen, Kristia ...
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Dahl-Jørgensen, ...
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